Nadal is through to a Grand Slam semifinal for the 5th time since turning 30, while Djokovic has reached the last 4 at a major for the first time since his 30th birthday.
The two now-legendary players first met 12 years ago at the French Open but that quarter-final was something of an anticlimax thanks to a back injury that forced Djokovic to retire when already trailing by two sets to love.
Wimbledon 2018 has been nothing short of a spectacle so far. The two will play at Wimbledon on Friday for the third time, with their record an even 1-1.
"He is one of the more complex players that I ever saw on our sport".
Nadal and Djokovic will battle for Sunday's final on the same court at 4pm.
Is Djokovic back? Nadal will fear Djokovic, who has been improving with each tournament this year.
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Nadal, meanwhile, is appearing in his first Wimbledon semifinal since 2011.
Since elbow surgery last year and another procedure after his struggles at the Australian Open, the 31-year-old has remodelled his serve and looks close to his best form again at Wimbledon this year. The final score line read 7-5, 6-7, 4-6, 6-4, 6-4 in favor of the 17-time Grand Slam champion.
When the 4 hours, 48 minutes of diving across the grass and leaping into the stands, of slipping and sliding, of so many moments of great tension - and, above all, great tennis - were done, when Rafael Nadal had sealed his Wimbledon quarterfinal victory, the man he edged, Juan Martin del Potro, was face-down at a Centre Court baseline.
"I'm trying to get to where he's already been", said Isner, who has won all 95 of his service games this fortnight, thanks in part to a tournament-leading 161 aces.
The video showed the three-time Wimbledon champion playing marbles with his support team. Because of the length of the first match, that semifinal will be played with the roof closed.
South Africa's Kevin Anderson will square-off against John Isner. The surprise elimination of Roger Federer has opened the door for any of the four remaining players to step through it and raise the Wimbledon trophy. I knew I was in a good spot.
"I think it was great quality tennis, the final set was there were some unbelievable points".