The Swiss ace needed just over an hour and a half to book a fourth-round spot by beating the big-serving German 6-3 7-5 6-2.
However, Cilic suffered a dramatic exit at the hands of Guido Pella on Thursday afternoon to fall early.
Keys also came up short with a comeback attempt after fighting back from a set and two breaks down, losing 7-5, 5-7, 6-4.
The solitary break of the opener proved enough for Federer to take the initiative in the contest.
While the result was bad news for Cilic, Federer must have been watching with a wry smile as he avoided the Queen's champion.
But his defeat is good news for defending champion Roger Federer, who was on course to face Cilic in the semi-finals.
"The rain coming helped me a lot", the 28-year-old, who had not won a match at Wimbledon in his two previous visits before this year, told BBC Sport. I always expect to come out and do the best I can do and that's all I can hope for'.
"Today, I started to play more aggressively and fight for every ball and that is why I won".
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He pledged to pursue responsible economic policies , respect private property and guarantee individual liberties. He invested in infrastructure, built schools, and cut tax breaks to developers to gentrify the downtown.
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Interviewed on NBC's Meet the Press , Lindsey Graham of SC said North Korea would "regret it" if nuclear talks collapsed. Immediately following the summit, Trump was quick to claim there was "no longer a nuclear threat from North Korea".
India Vs Ireland today's match | India cricket match
Siddharth Kaul was in the Indian squad for the home ODIs against Sri Lanka in December, but was not picked ahead of Kumar-Bumrah. Meanwhile, 31-year-old Punjab-born off-spinner Simranjit Singh will enjoy the spotlight of playing against his erstwhile nation.
"Just ran out of time in the end", Venus said.
"I went on court with the determination to play at the right intensity".
Del Potro showed he is shaping up nicely for tougher matches ahead with a 6-4 6-1 6-2 romp past Spanish veteran Feliciano Lopez to reach the third round at Wimbledon on Thursday.
Nadal breezed into the competition's second round with a 6-3, 6-3, 6-2 win over the world number 127.
Keys, who was the US Open runner-up past year, crashed out 7-5 5-7 6-4 to the Russian on a baking hot Court Three.
He will face Australian teenager Alex De Minaur in the next round.
Rodina made the fourth round of a Grand Slam for the first time.
If anyone doubted Serena Williams was worth consideration as a victor of this tournament for an eighth time - let alone the 25th seeding that has caused a minor stir in the locker room - she provided the most emphatic statement of intent with her third straight-sets win of the week to reach the fourth round on a wave of growing self-belief.