USA experts said their country is making a full-on effort to force Iran's hand.
"The insignificant, insulting and secondary remarks of the new US Secretary of State and his unacceptable attitude to the great and civilized Iranian nation testify to the US government officials' despair and helpless stance on the Iranians", the statement read. "The leaders in Tehran will have no doubt about our seriousness", Pompeo said in a speech at the conservative Heritage Foundation think tank.
The Donald Trump administration's new strategy on Iran is a series of tough demands and belligerent threats that is likely to bolster Iranian hardliners and increase instability in the Middle East.
Trump denounced it as "the worst deal ever" for failing to curb Iran's separate ballistic missile programme and its influence in Syria, Yemen, Iraq and Lebanon.
According to the statement, "the USA government will be responsible for the consequences of any persecution as well as unlawful and violent actions against the Iranian nation". "The world today does not accept that the United States decides for the world. Countries have their independence", he added.
The Iranian counterpart Javad Zarif said the U.S. was a prisoner of its "failed policies" and would suffer the consequences European Union foreign policy chief Federica Mogherini said Pompeo had not demonstrated how abandoning the deal made the region safer from nuclear proliferation.
He also called for a full stop to Iran's enrichment of uranium, which was sharply curbed by the Iran deal, and for global monitors to gain "unqualified access" to all sites, including military facilities that Iran considers off-limits.
"We want to hear your concerns", Pompeo said.
In his first speech as secretary of state, Pompeo called for the Iranian people to oppose their government.
These essentially address every aspect of Iran's missile program and what the U.S. calls its "malign influence" across the region, including support for Syrian President Bashar al-Assad, Hezbollah and Huthi rebels in Yemen.
Maas said he will travel to Washington to talk with Pompeo this week.
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"The US policy is correct". "The [Iranian] regime has been fighting all over the Middle East for years. It aspires to achieve nuclear weapons by various means", Netanyahu said as he met Paraguayan President Horacio Cartes in Jerusalem.
Salehi said "until these promises are not implemented and put into practice, we can not speak firmly".
"Iran, meanwhile, is working with partners for post-US JCPOA solutions", he added.
"We want to insist on the freedom of all political prisoners in Iran". "But you should know that we will hold those doing prohibited business in Iran to account".
Rouhani said in a statement published by Iranian state media on Monday. "The pressure on European companies from the U.S.is quite large", he told reporters in Brussels.
The EU has been trying to persuade Iran to stay in the 2015 agreement, even without Washington's participation.
Germany's economy minister earlier told a newspaper the Berlin government would help German firms with business in Iran where it could, but could not entirely shield them from the US decision to quit the Iran nuclear deal and reimpose sanctions.
"The JCPOA is the result of more than a decade of complex and delicate negotiations, based on dual track approach and therefore the best possible outcome, striking the right balance", Mogherini said.
"Pompeo has not outlined a strategy, but rather a grab bag of wishful thinking that can only be interpreted as a call for regime change in Iran", said Suzanne Maloney, an Iran expert at the Brookings Institution.
Critics rounded on Pompeo's speech, saying his demands could have been made without pulling America from the nuclear deal.
"We are assessing if we are going to double down on current actions or implement new actions." said the spokesman, Colonel Robert Manning.
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