He was 23 months old.
Evans died after his parents lost their final battle in court to prevent doctors from turning his life support machine off. Alder Hey Children's Hospital in Liverpool, England, where he had been getting treatment, concluded it would be futile to treat him further. The country's High Court ordered the toddler's life support to be terminated on Monday, then refused a request by his parents to seek experiment treatment elsewhere on Tuesday.
December: Alfie is taken to Alder Hey Children's Hospital after suffering seizures.
Despite support from the worldwide community and even an offer from the Pope and doctors at a hospital in Rome, the United Kingdom courts upheld the ruling against Alfie and his parents. Earlier this month, Evans met with Pope Francis in Rome and asked the pontiff to make a trip to Liverpool to see his son.
The Holy Father tweeted: "It is my honest hope that everything necessary may be done in order to continue compassionately accompanying little Alfie Evans, and that the deep suffering of his parents may be heard".
However, judges sided with doctors who said there was no chance of recovery.
"Our lives have been turned upside down by the intense focus on Alfie and his situation", Evans said Thursday outside Liverpool's Alder Hey Children's Hospital, where Alfie was treated for more than a year.
"I am deeply moved by the death of little Alfie".
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"The Alfie Evans case is extremely hard for all involved; heartbreaking for his parents and emotionally challenging for the doctors and nurses involved in treating and caring for him", it said. "We are heart broken", his mother, Kate James, posted on Facebook.
Alfie Evans, the British toddler whose medical case garnered worldwide attention, died Saturday morning.
He thanked the hospital staff "for their dignity and professionalism during what must be an incredibly hard time for them too".
"Thomas [Sarah's brother and Alfie's dad] just wants to thank you all for the support you've all shown".
The parent's fight to get medical care for their child attracted the attention of a number of USA political figures, especially conservatives.
April 23: The European Court of Human Rights refuse the application made by Alfie's parents, saying: 'The European Court of Human Rights has today rejected the application submitted by the family of Alfie Evans as inadmissible'.
Thousands paid tribute on social media, with RIP Alfie Evans trending all morning, but their comments were often highly polarised over the courts' decisions.
A group of about 200 protesters tries to storm Alder Hey hospital, where Alfie has been receiving treatment.