The former first lady of the United States' family is by her side after her health took a recent turn for the worse.
"Following a series of hospitalisation, and after consulting her family and doctors, the 92-year-old has decided not to seek additional medical treatment", Efe news quoted spokesman Jim McGrath as saying on Sunday.
She has had a series of recent hospitalizations, but the family did not provide details about her condition.
Bush, 92, is being cared for at her home in Houston and has decided she does not want to go back into the hospital.
Barbara Pierce Bush is the wife of the 41st President of the United States, George H.W. Bush, and served as First Lady of the United States from 1989 to 1993. She's been battling Chronic Obstructive Pulmonary Disease and congestive heart failure.
After George W. Bush became the 43rd president in 2001, he would fly into Sanford Regional Airport and ride in a motorcade to stay in Kennebunkport as the family compound came under the worldwide spotlight once again.
Ailing Former First Lady of the United States Barbara Bush has chose to be in comfort care than seeking medical assistance. "Praying that she is comfortable & send love to President Bush & their family".
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Over her decades in the public spotlight, Mrs Bush became a renowned and respected philanthropist and a keen advocate for literacy.
"She's the kind of person.grandmotherly, ready to help, but very careful not to step on anybody's toes", Rosenbaum says.
Barbara Bush has been married to her husband for 73 years. Another son, Jeb Bush, was governor of Florida and unsuccessfully ran for president in 2016.
With hair that had turned white prematurely, Bush was known by family members as the "Silver Fox".
Bush is one of only two first ladies who was also the mother of a president.
Earlier in 2017 he was at Houston's Methodist Hospital for 16 days, also for pneumonia.