Virginia in the South was ousted in a historic upset by No. 16 seed UMBC.
Mid-majors can not be taken lightly in March, as a praying power has created a staying power for one.
No. 7 seed Texas A&M is another team added to the large number of teams who pulled off an upset over the weekend by defeating No. 2 seed North Carolina 86-65 in a blowout win.
This is the purest of all tournaments and perhaps the most exhilarating too.
Looking ahead to the second round of action, which games were played on Saturday and Sunday, the drama didn't stop.
While the Final Four could look something like this - Kentucky versus Gonzaga and Villanova versus Duke - once again there are no guarantees.
No. 2 Duke, the third favorite in some oddsmakers' books to win it all entering the field of 68, starts four freshmen.
United States retailers warn Trump over negative impact of China tariffs
"The crops that we grow here on this farm are exported across the globe", Montana farmer Michelle Erickson-Jones says in the ad. RILA's president, Sandy Kennedy, meanwhile said tariff could hurt the U.S. retail industry.
FSU Basketball NCAA Tournament 1st Round Preview: vs. Missouri
Leading scorer and rebounder Terance Mann did leave the game after slipping to the floor in the second half and did not return. That would up as part of a 20-4 spurt capped by a 3-pointer by Braian Angola midway through the half.
Simona Halep, Venus Williams stunned by Naomi Osaka, Daria Kasatkina
She was broken to open the second set and again in the fifth game, giving Osaka a 4-1 lead on her forehand victor down the line. Interestingly, this was the Japanese's first singles title of any kind, and she has not triumphed on the ITF level either.
Fellow ACC team Virginia opened as the tournament favorite, but the Cavaliers became the first No. 1 seed to lose to a No. 16 seed in the first round Friday night, falling hard to Maryland-Baltimore County. The Mountaineers will play top-seeded Villanova in the East semifinals, with second-seeded Purdue and third-seeded Texas Tech meeting in the other game.
With just 16 teams left, though, who is the best of the bunch?
With Kansas being one of the more vulnerable top seeds left in the tournament, the No. 2 Duke Blue Devils could find themselves knocking on the door of yet another Final Four appearance if they can get past No. 11 Syracuse and beat the victor of No. 1 Kansas vs. Not only was Virginia a No. 1 seed but also the No. 1 team overall and UMBC did it in dominating fashion, winning by 20.
The first 11th seed to make the Final Four was LSU, who enjoyed their star-crossed run in the Southeast Region after going 9-9 in the SEC.
Kentucky's path to a Final Four may be the easiest slate a perennial powerhouse has seen on paper, needing a win over Kansas State then another over Loyola-Chicago/Nevada, but still this is the time of the year when what you think will happen often does not.
No.1 Kansas isn't favored to win the Midwest.
Brackets are busted, No. 1 seeds have fallen but the craziest part of this year's March Madness is at that the tournament has only just begun.
The insane twists and turns are sure to follow as play resumes this Thursday, with Sister Jean's team opening up the action in Atlanta.