OH firefighter Miocic dominated Ngannou over five punishing rounds in the main event of UFC 220 in Boston, Massachusetts to claim a landslide unanimous decision victory and retain his title for the third successive time.
In what turned out to be a dominant performance, Miocic became the first man to defend the UFC heavyweight championship on more than two occasions as he claimed a unanimous decision victory over the Cameroonian-French mixed martial artist.
Stipe Miocic (17-2) looks to set a UFC heavyweight division record with a third straight successful title defense when he fights Francis Ngannou (11-1). All three judges ringside scored the fight 50-44 for Miocic.
The co-main event is another title fight as Daniel Cormier defends the light heavyweight championship against Volkan Oezdemir.
On the main card's opener, bantamweight Rob Font kicked, punched, and hammerfisted his way to an upset second-round stoppage of Thomas Almeida at 2:24 of a second round that witnessed the local hero send the Brazilian summersaulting before ultimately sending him to the showers.
Gian Villante edged out fellow heavy-hitter Francimar Barroso with a split decision win in a light heavyweight clash that most fans and analysts did not predict would see the final bell.
But by defeating Oezdemir, Cormier added him to a list of victims that includes Anthony "Rumble" Johnson twice, Alexander Gustafsson, Anderson Silva, Dan Henderson, Roy Nelson, Frank Mir, Josh Barnett and Antonio "Bigfoot" Silva. Hard right hand from Cormier. The referee stepped in to stop the fight at 2:00 of Round 2.
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Oezdemir walked to the cage with his native Swiss flag draped over his shoulder to nearly no reaction from the Boston crowd.
The TD Garden was packed and lit from the opening preliminary bout and the card was sprinkled with MA fighters that sent the crowd into a frenzy with each introduction.
The UFC had five fights ahead on the UFC 220 pay-per-view card.
Islam Makhachev needed just one left hand and 57 seconds to knock out Gleison Tibau in the first preliminary bout.
'Khabib Nurmagomedov gets a title in a couple of months, and by the end of the year Cain Velasquez is going to be fighting for the UFC heavyweight title again. If he can return later this year, that would be a matchup for the ages.
In his five previous fights, Miocic won by knockout or technical knockout, and four of those bouts ended in the first round. Ngannou fights just seven weeks after his stunning victory of Alistair Overeem at UFC 218.
It was the fifth UFC event held at the TD Garden and marked the highest attendance ever for the company.