"In the first half the referee could have given a penalty and in the second half we could not take advantage of a counter-attack in the last minute".
Wilshere, Walcott and Giroud have all spoken about their frustration at a lack of game time in the Premier League - with France striker Giroud now being picked for his country as the England duo look like missing out on the World Cup at this moment.
"I can not consider too much the interest of the national team, even if I support France".
Arsenal have no players suspended for this game.
Following their draw against Bournemouth last week, Southampton find themselves in 11th place, nine points behind Arsenal who sit in fifth spot.
Granit Xhaka and Aaron Ramsey will be the central midfield pairing while Hector Bellerin and Sead Kolasinac will start in the wing-back slots.
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Giroud signed a new contract at Arsenal in January and said in the summer that he was motivated to win more titles with the club.
His record of four goals this season despite zero starts in the Premier League means he's scored a goal every 63 minutes.
Charlie Austin's early fine finish looked set to earn Southampton all three points at St Mary's, but with just two minutes left on the clock, Olivier Giroud's header salvaged a point for the visitors.
"Last week had an influence on today's game", Arsenal manager Arsene Wenger, whose side played in the Europa League on Thursday, told Sky Sports television.
- Arsenal have conceded 32 Premier League goals away from home in 2017.
The match is being televised on BT Sport in the UK while NBCSN will carry the match in the United States, with kickoff at 12:00 GMT (07:00 ET).