Should they trip up, there's no doubt questions will be raised over whether Pochettino and his men can go all the way on the main stage - after all, the Argentine remains trophy-less at Tottenham.
Tottenham finished above Arsenal in the Premier League last season - the first time that had happened since Wenger took charge of Arsenal in 1996 - and is three places and four points ahead of Arsenal after 11 games of this season. For what seems like the first time in decades, Tottenham is widely regarded as a clear favorite even though the match is taking place at Arsenal's Emirates Stadium.
Tottenham have a series of injury doubts ahead of the crucial clash, with a host of big-name players having sat out the global break.
Arsenal head into Saturday's game looking to get back to winning ways in the Premier League after their 3-1 defeat by Manchester City at The Etihad before the worldwide break.
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One student at the elementary school was hit by gunfire and transported to the local hospital for treatment, Johnston said. Separately, three people were being treated at a hospital in Redding, about 80km north of the shootings.
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Meanwhile, in Group A, Tunisia played out a tense goalless draw with Libya to edge Congo DR to top spot by just one point. But it proved to be enough and, after missing out in 2010 and 2014, Tunisia will be at the World Cup for a fifth time.
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During the bye week I got off anti inflammatories to clean my system and could really feel the pain. "We know our ultimate goal". While he is fourth on the team with 24 receptions for 233 yards, his biggest contributions came in the run game.
"Not at all", said the Arsenal manager when asked if his side are the outsiders for victory this weekend.
Tottenham fans have been discussing a "powershift" in the north of the London following last season's league standings.
"Not at all. I think Tottenham is a good side but we have the quality to win this game and that is what we want to show", he told reporters. They enter Saturday in danger of doing that for the first time this year, having also lost at Old Trafford on October 28. "They were great (in the) Arsene Wenger era, and I think for us it's a massive challenge to stay there and to be competitive against a team that, in the last 20 years, wins more trophies than us".
And how does the defence cope with Harry Kane, should the Spurs ace be fit to play?
Alexandre Lacazette was heralded as the saviour of Arsenal when he was brought into the club from Lyon during the summer.