I don't think he'll be available before the next worldwide break.
Watford are yet to win at home this season while the Gunners haven't won on their travels, meaning the match could be a tight affair. I want to win as many trophies with Arsenal as possible. Watford are 17/4 for victory which look like great odds.
Watford have been excellent this season, but they are perhaps facing Arsenal at the wrong time.
Arsenal were dealt a fresh blow in terms of an injury during the global break when Mustafi hobbled off with hamstring trouble while playing for Germany.
Both sides have a number of injuries heading into the game, but Arsenal's squad depth could be a major deciding factor. Mustafi's value is hard to overstate as Arsenal (4-1-2) have recorded clean sheets in their last four league contests with the Germany global anchoring the central defence.
Watford could be without as many as four first-team defenders on Saturday.
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Alexis Sanchez is a slight doubt for the Gunners due to fatigue following the global break.
"I know that we have to adapt to the schedule dictated by the television, but overall I would say if that happens personally I think it should not be played after 2 p.m. latest on Christmas Eve", Wenger said.
"Koscielny has a definite final test tomorrow but at the moment he is not available".
Arsenal geared up for their first match back after the worldwide break with a full-blooded training session as Alexis Sanchez put the disappointment of missing out on World Cup qualification behind him alongside his club team-mates.
The Gunners are hopeful that Sead Kolasinac will be okay despite being forced off at half time for Bosnia on Tuesday.