But Messi's XI is in more danger than others, considering they face the threat of Ecuador in Quito during the final round of matches on Tuesday night.
The visitors have a poor record on the road against Ecuador but need a victory to sustain their ambitions of a trip to Russian Federation next summer or at least better the results of Chile, Colombia and Peru.
Meanwhile, Brazil striker Gabriel Jesus insisted that they will play to beat Chile, which will boost Argentina's chances of qualification.
The top four qualify automatically from South America with fifth place going into a play-off with a team from Oceania.
As things stand, those two matches would take place in Wellington on November 8 with the return in Buenos Aires on November 15.
A defeat in the final round of qualifying to be played at high altitude with some 9,000 feet above the sea-level, will put Messi and co probably out of the next World Cup in Russian Federation. It is now 456 minutes since any Albiceleste player found the net from open play, and despite being heavy favourites against Peru in their last game, they were inept in attack, even with five-time Ballon d'Or victor Messi pulling the strings.
Argentina are yet to win in the Qualifiers since the arrival of Jorge Sampaoli.
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"Argentina have played the last few matches as if they been running in treacle". It would be a test of nerves for the Argentines as they will have to combat all odds to make it to the World Cup, under challenging conditions, against a team playing for pride.
Copa America champions Chile (26 points) are third, behind inconsistent Uruguay (28) and group winners Brazil (38), while seventh-placed Paraguay (24) also remain in contention.
"The team that hauled itself to the World Cup final three years ago was heavily reliant on the inspiration of Messi and the grit of Javier Mascherano".
Brazil are already qualified.
Argentina need to win the match to keep themselves alive.
"Messi is extraordinary but he is yet to win a World Cup", he told newspaper La Nacion.
Ecuador only have pride to play for but are always a tough opponent at home. For that to happen, they need their star players to appear when it matters the most. A draw and even a loss could be enough for a playoff spot, depending on other results.