Spanish Deputy Premier Soraya Saenz de Santamaria on Monday warned that a possible declaration of independence issued tomorrow in Parliament by Catalan President Carles Puigdemont would "not remain unanswered".
Spain's Prime Minister Mariano Rajoy could suspend the existing autonomous status that Catalonia enjoys under the country's system of regional governments.
Benet Salellas of the separatist Catalan CUP party said: 'It's very clear to me that those who I represent won't accept any other scenario'.
Mr Sanchez said "a unilateral declaration of independence doesn't have a place in a state ruled by law".
"We have said yes to so many mediation options that have been proposed", he said.
Pressure mounted on Monday against Catalan vow to break away from Spain after hundreds of thousands of protesters rallied to defend national unity, but the region's leader maintained his threat to formally declare independence possibly within days.
"The unity of Spain can not be voted on or negotiated - it must be defended", read one sign in the crowd.
"They say the point is to have an independent country because it will be better", Gonzalez told NPR.
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"This crisis needs to be resolved through dialogue at all levels of Spanish politics", she urged.
Although the Catalan government are of the opinion that over 90% of voters voted in favour of independence, opinion polls and analysts are of the the opinion that this may not be the case as only 43% of registered voters turned up for the referendum.
Caixabank, Spain's number 3 bank, and Banco Sabadell, the number 5, have both moved their head offices out of Catalonia last week following an independence referendum that the Madrid government attempted to block. It is home to 7.5 million people and accounts for about a fifth of Spain's economy.
Rajoy says he would only hold talks with Puigdemont's side if the Catalan separatists abandoned their independence bid in line with the Spanish constitution.
Puigdemont hinted in an interview on Sunday that the region would go ahead with the declaration if Madrid continued to refuse dialogue.
Meanwhile, Nils Muizneks, the Human Rights Commissioner of the Council of Europe, revealed that he has requested Spain's Ministry of the Interior set up an independent enquiry into multiple claims of disproportionate use of excessive force by the Spanish police during the banned referendum on 1 October.
Despite the outrage, Rajoy and Spanish King Felipe VI defended the police and doubled down on their stance to take whatever measures necessary to keep Catalonia from seceding.
But Rajoy assured Catalan leaders that there "is still time" to backtrack and avoid the imposition of direct rule.