Firefighters responded to the rooftop blaze at the luxury resort famous for its fountain display just before 11pm local time.
There has been no reported injuries and the cause of the fire is still unknown.
The case of the fire remains under investigation.
Monet says employees evacuated from stores like Tiffany & Co. and Chanel, but operations weren't interrupted at the casino and the 36-story hotel. Damage was limited to the roof.
Hotel spokeswoman Yvette Monet (moh-NAY') says the retail area was evacuated, but operations weren't interrupted at the posh casino and hotel with almost 4,000 rooms.
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The fire was contained to the exterior roof of a high-end retail section of the building. Fire officials closed down traffic on the strip for an hour to attend to the fire. Clark County Fire said firefighting efforts were "extremely difficult" due to the location of the fire and access to the location.
It wasn't immediately clear if the building material was the same type that burned in a January 2008 fire atop the Monte Carlo hotel-casino a few blocks away, Haydu said.
That fire was sparked by welders on the roof.
Additionally, none of the hotel's 3,950 rooms were affected and no mass evacuation was called.