But he's healthy now, and after playing in just 11 games last season, Brantley made the most of his first home game since May 10 with his game-winning hit.
A day after registering a 2-1 win to open the series against the Twins, the Tigers took another contest versus Minnesota.
Tigers: RHP Jordan Zimmermann (1-0) makes his second start of the season.
Minnesota has dropped two of its last three after a promising 4-0 start helped erase the memory of losing nine straight to open last season, leading to a 59-103 finish. Francisco Rodriguez threw a somewhat shaky 9th inning, giving up 1 earned run on 3 hits but got the job done for his 3rd save of the season.
The Tigers (5-2) have now won four of their last five.
Boyd (1-1) did not allow a hit until Robbie Grossman lined a clean single to left field with two out in the sixth.
The third baseman just missed out on a home run in the bottom of the fourth inning as he smacked a baseball to left-center. The Twins plated one on back-to-back hits from Miguel Sano - a double - and Jason Castro - a single. Before that, though, Tyler Collins put in a key at-bat with one out and the bases loaded that gave him that chance in the first place.
Rodriguez allowed a single to Joe Mauer and then retired the next two men.
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Tigers: Manager Brad Ausmus said OF J.D. Martinez (sprained right foot) swung in the batting cage Monday.
NATIONALS 8, CARDINALS 3: Daniel Murphy homered, doubled twice and tied career highs with five RBIs and four hits and the Washington Nationals defeated the St. Louis Cardinals 8-3 on Tuesday night. The other time was 2014.
Minnesota's Byron Buxton struck out in all three of his plate appearances and is now 2-for-29 with 17 strikeouts.
Closer Brandon Kintzler was hoping to be available on Tuesday after cracking the nail on his right index finger during Sunday's four-out save in Chicago. The team was off Monday, and he did not pitch Tuesday with Minnesota trailing.
During Boston's visit to Comerica Park, several Sox coaches, roughly half a dozen players and TV broadcaster Dave O'Brien became ill.
The hotel at which both visiting teams stay also took precautions.
Dropping consecutive games for the first time this season, the Twins fell a game behind the Tigers in the early American League Central standings.
"I don't remember the bat flip", he said afterward.