U.S. Secretary of State Rex Tillerson said that Russian Federation failed to live up to its agreement in a chemical weapons accord.
The CBS host pressed Tillerson on saying there's been no change in policy regarding Assad, wondering if he was stating that the Syrian president's fate should be determined by the Syrian people.
This week's airstrike "was a message to Bashar al-Assad that your multiple violations of your agreements at the United Nations, your agreements under the chemical weapons charter back in 2013, that those would not go without a response in the future", he said.
Russian President Vladimir Putin also sees the latest United States missile strikes on a military airfield in Syria as an attempt to distract from the mounting civilian casualties in Iraq, the Kremlin added.
"I don't draw conclusions of complicity at all, but clearly they've been incompetent and perhaps they've just simply been out-maneuvered by the Syrians", Tillerson said in an interview with ABC's This Week programme. The Syrian government has denied it was behind the attack.
Hundreds more suffered symptoms that the World Health Organization said were in some cases consistent with exposure to chemicals that include nerve gas.
Assad's government signed the Chemical Weapons Convention and agreed to turn over its chemical armaments in 2013, after being accused of a sarin attack outside Damascus that killed hundreds of people.
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"Part of the discussions when I visit Moscow next week is to call upon Foreign Minister Lavrov and the Russian government to fulfill the obligation it made to the worldwide community when it agreed to be the guarantor of the elimination of the chemical weapons; and why Russia has not been able to achieve that is unclear to me".
The comments came in a phone conversation with Iranian President Rouhani who called the Syrian leader to voice his strong condemnation of what he called the "US' blatant aggression" on Syria.
Moscow has said it doesn't believe Assad's forces carried out the attack on Thursday that involved children and called for a "thorough and impartial" investigation.
Both leaders also said they backed "an objective inquiry" into the Khan Sheikhun incident has also caused a diplomatic spat between Moscow and London.
And on Sunday, British Defence Secretary Michael Fallon accused Russian Federation of being responsible "by proxy" for deaths in the suspected chemical attack.
In addition, a bomb killed one woman and wounded 25 others in the city of Homs, officials said.