The Cardinals led in the seventh inning when Cecil got Cubs pinch hitter Matt Szczur to strike out on a pitch in the dirt.
At the time, the Cardinals laughed off the freaky play even though it resulted in pinch hitter Matt Szczur reaching base.
The Cubs did not ask umpire Quinn Wolcott to check the ball, didn't seem particularly surprised and assumed that Molina was simply using a sticky substance to get a better grip on the ball, given the blustery conditions.
Cardinals catcher Yadier Molina and most everyone else at Busch Stadium laughed at the freaky sight - a ball somehow stuck to his chest protector, in plain view of everybody except him. The Gold Glove catcher could only smile and fans in sellout crowd laughed really, who'd ever seen such a thing? He walked Jon Jay on a 3-2 pitch and then Schwarber destroyed the next pitch, rifling it 404 feet into the right field seats for his first homer.
Snell gave up five runs and four hits in 6 2/3 innings.
Addison Russell's infield out in the sixth made it 4-2 St. Louis, and he added a second RBI grounder an inning later to cap the scoring. The Cubs added another run later in the inning against Cecil (0-1).
Puig, who was demoted to the minors last season, hit two two-run home runs and also scored three times.
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All this came after John Lackey had what we might call "the typical Lackey first inning", though some of it wasn't his fault. Stroman (1-0), the MVP of last month's World Baseball Classic, allowed one run and six hits in his 2017 debut. The Cubs slugger is 0 for 13 this season.
His seventh-inning blast was the difference in this game.
That much was made clear by what manager Joe Maddon called a "raucous" postgame celebration, with teammates singling out Schwarber for more than just his mammoth homer.
Matt Adams and Randal Grichuck followed up Zobrist's error with consecutive singles, and by the end of the inning, the Cardinals had batted around and plated three runs. Carpenter is still working to regain his stroke after struggling with a minor back injury during spring training. "There's a long way to go, but it was definitely a good win for the team and to get momentum going into the next series".
The 14-year-veteran's reaction in trying to locate the ball had a touch of Benny Hill about it, with the eight-time Gold Glove victor totally baffled by the case of the missing ball.
Brett Anderson will make his Cubs debut on Friday against the Brewers and he will be opposed by Jimmy Nelson.
The Rockies won three of four games in the season-opening series.