Two people, including a toddler between 2 and 3 years old, were killed, police said.
The nephew and her boyfriend, who has not yet been named, were shot in the head and were later pronounced dead at Stroger Hospital. A 20-year-old woman was also hospitalized after she was shot in the stomach. Guglielmi said she is pregnant and that both she and her unborn baby are now in fair condition.
All three victims were shot inside of a auto that was in an alley.
"We have very promising leads", Johnson said at a news conference. The woman runs from the vehicle screaming and yells that she has been shot in the stomach. Another girl, Kanari Gentry Bowers, 12, was also wounded over the weekend and has remained in critical condition and on life support.
The couple was live-streaming and singing to music in the auto when the shots started.
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The child was taken to the hospital where he later died.
The deadly Chicago shooting caught on Facebook Live video came the same day that another young girl was killed from an act of violence in the city.
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"My gut is telling me that when we finally find this guy, we're going to find that he's a repeat gun offender". She and her unborn baby lived, but the boyfriend - a gang member, according to police - died at the scene.
President Trump has repeatedly criticized Chicago's violence, and tweeted that he would "send in the feds" if the city did not fix the problem. Authorities have not released his name or the circumstances of the shooting. Since the beginning of 2017, there have already been at least 76 homicides.
Johnson and Mayor Rahm Emanuel have repeatedly blamed the violence on a combination of increased gang activity and weak gun laws that they say don't do enough to dissuade convicted felons from carrying and using weapons.